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In recent years, microneedle technology has been widely used in the research of transdermal drug delivery due to its unique mechanism of opening the stratum corneum barrier. Nanotechnology has also received extensive attention in the field of transdermal drug delivery due to its excellent solubility enhancement, high drug stability, targeted drug release, and sustained and controlled release properties. However, the researchers found that both technologies have obvious defects in transdermal drug delivery, such as inability of microneedle technology to improve the solubility of poorly soluble drugs, and poor stratum corneum penetration ability of nano-formulations, which will limit the application of the two technologies in transdermal drug delivery. At present, some scholars have tried to combine nano-formulations with microneedles to improve the physicochemical properties of drugs and achieve targeted drug delivery as well as controlled drug release, synergistically enhancing the effect of drug transdermal delivery and promoting the efficient application of drugs. Therefore, this article will briefly introduce the advantages and disadvantages of some microneedles and nano-formulations, and further summarize the advantages, applications, and prospects of nano-formulations combined with microneedles.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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