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To prepare and evaluate the polymer micellar thermosensitive gel of Chinese medicine chrysanthemum volatile oil.
The polymer micelles were prepared by the ethanol injection method, and the preparation process was optimized by orthogonal experiments. The morphology, particle size and zeta potential of the polymer micelles were evaluated. The thermosensitive gel was further prepared using poloxamer 407 and poloxamer 188 as the matrix. The rheological properties of the thermosensitive gel were measured by a flat plate rheometer, the irritability of the thermosensitive gel to rabbit eyes was investigated using Draize eye irritation score, and eye tissues were examined by pathological examination.
The optimal preparation process of Chinese medicine chrysanthemum volatile oil polymer micelles thermosensitive gel was as follows: the concentration of chrysanthemum volatile oil was 15 μL·mL-1, the mass ratio of surfactant (TPGS∶phospholipid) was 3∶2, the concentration of surfactant was 37.5 mg·mL-1, and the mass ratio of phospholipids (HSPC∶DSPE-PEG2000) was 1∶1. The polymer micelles were closely arranged, spherical or quasi-spherical with the average particle size of (58.60±2.37) nm and zeta potential of (0.197±0.045) mV. The thermosensitive gel prepared with 21% mass fraction of poloxamer 407 and 3% mass fraction of poloxamer 188 was a pseudoplastic fluid with good rheological properties. The gel was basically non-irritating to rabbit eyes and had no irreversible tissue damage.
The prepared TCM chrysanthemum volatile oil polymer micelle thermosensitive gel has little irritation and good stability.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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