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Research progress of calcium nanoparticles in tumor immunotherapy
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Wei-wei ZHI1, Xia-li ZHU1, Yong-yan JIA1, Zhi-ling XU1, Yi-jing LI1, Sheng-nan HUANG2, 3
Chinese Journal of New Drugs | 2023, 32(12) : 1220 - 1227
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Chinese Journal of New Drugs | 2023, 32(12): 1220-1227
Research progress of calcium nanoparticles in tumor immunotherapy
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Wei-wei ZHI1, Xia-li ZHU1, Yong-yan JIA1, Zhi-ling XU1, Yi-jing LI1, Sheng-nan HUANG2, 3
Affiliations
  • 1Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 3School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou University, Zhengzhou 450001, China
Published: 2023-06-30
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Tumor immunotherapy holds immense potential for tumor treatment because it can utilize the patient's immune system to eradicate tumors and prevent tumor recurrence. Nanoparticles are expected to be the optimal carrier for tumor immunotherapy due to their unique advantages. Ca2+, as the second messenger in cells, plays an important role in regulating the immune response in vivo. Recent studies have shown that calcium nanoparticles, such as calcium peroxide (CaO2) nanoparticles, calcium phosphate (CaP) nanoparticles, calcium hydride (CaH2) nanoparticles and calcium carbonate (CaCO3) nanoparticles, can activate anti-tumor immune responses through a variety of mechanisms. In addition, calcium nanoparticles can also be used in combination with other therapies such as photothermal therapy (PTT), sonodynamic therapy (SDT), chemotherapy and radiotherapy to synergically fight tumors to exert the "immune+" anti-tumor effect. In this article, we reviewed the recent research progress of calcium nanoparticles in tumor immunotherapy, and looked forward to the challenges of this field.

calcium nanoparticles  /  tumor immunotherapy  /  combined therapy  /  immune+
Wei-wei ZHI, Xia-li ZHU, Yong-yan JIA, Zhi-ling XU, Yi-jing LI, Sheng-nan HUANG. Research progress of calcium nanoparticles in tumor immunotherapy[J]. Chinese Journal of New Drugs, 2023 , 32 (12) : 1220 -1227 .
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Year 2023 volume 32 Issue 12
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  • Online Date：2026-03-06
  • Published：2023-06-30
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  • Accepted：2022-08-08
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    1Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
    3School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou University, Zhengzhou 450001, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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