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To study venous thromboembolism associated with risperidone in the treatment of schizophrenia, so as to provide references for future clinical rational drug use.
A case of risperidone-associated pulmonary thromboembolism was presented and the cases of risperidone-associated venous thromboembolism, deep vein thrombosis and pulmonary thromboembolism were collected from Chinese VIP journal database, Wanfang and PubMed database and analyzed.
A total of 13 cases were retrieved. Risperidone-induced venous thromboembolism has been reported in all age groups, and the dose ranged from 1 to 6 mg. Adverse reactions occurred within 2 months after the medication (10/13 cases), and the clinical manifestations were mainly respiratory symptoms or symptoms related to lower limb venous thromboembolism, such as lower limb edema and pain. Severe cases led to syncope, cardiopulmonary arrest or even death.
Clinicians and pharmacists should be familiarized with the characteristics of pulmonary thromboembolism associated with risperidone, weigh the advantages and disadvantages, and use it with caution. To reduce the occurrence of adverse reactions, coagulation function monitoring and venous ultrasound examination of lower limbs should be strengthened, and CT pulmonary angiography should be performed if necessary.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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