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to investigate the therapeutic effect and possible mechanism of baicalein on ulcerative colitis induced by dextran sulfate sodium salt (DSS) in mice.
A total of 42 male BALB/c mice were randomly divided into 6 groups (n=7), including control group, model group, baicalein groups (low-dose, medium-dose and high-dose) and mesalazine group (positive). The UC model of mice was established by 4% DSS. After the model was successfully established, the control group and the model group were given distilled water ad libitum, baicalein suspension of 10, 20, and 40 mg·kg-1, and the positive drug mesalazine 600 mg·kg-1, ig, for 14 days. The disease activity index (DAI) was calculated and evaluated, the changes of colon histopathology were observed by hematoxylin-eosin (HE) staining, and the levels of lipopolysaccharide (LPS) and secretory immunoglobulin A (sIg A) in serum were measured by ELISA. The expression levels of interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and nuclear factor of activated B(NF-κB) were detected by Western blotting.
Baicalein decreased DAI index of UC mice, decreased the protein expressions of IL-6, TNF-α and NF-κB in colon tissue, decreased the serum levels of LPS, and increased the content of sIg A in serum.
Baicalein reduced the inflammatory response and enhanced the immunity of UC mice, and the mechanism is related to regulating the expression of NF-κB in colon.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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