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Literature survey of perampanel-related treatment emergent adverse events
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Ling DING1, Li-hua LIU2, Xing LUO1, Fang HUANG1, Xian-jing TANG1, Fang-fang BI3
Chinese Journal of New Drugs | 2023, 32(3) : 323 - 328
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Chinese Journal of New Drugs | 2023, 32(3): 323-328
Literature survey of perampanel-related treatment emergent adverse events
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Ling DING1, Li-hua LIU2, Xing LUO1, Fang HUANG1, Xian-jing TANG1, Fang-fang BI3
Affiliations
  • 1Department of Neurology, The Third Hospital of Changsha, Vascular Disease Control And Prevention Institute of Changsha, Changsha 410015, China
  • 2Department of Pharmacy, The Third Hospital of Changsha, Changsha 410015, China
  • 3Department of Neurology, Xiangya Hospital Central South University, Changsha 410008, China
Published: 2023-02-15
Outline
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Objective:

To analyze the characteristics of perampanel-related treatment emergent adverse events (TEAEs), providing references for clinical rational drug use.

Methods:

The literatures about TEAEs caused by perampanel were retrieved from databases like CNKI, Wanfang, VIP, PubMed, ScienceDirect and Web of Science. The cases were divided into treatment group and overdose group according to the drug dose.

Results:

A total of 20 literatures including 25 cases were reported, with 14 cases in the treatment group and 11 cases in the overdose group. Most TEAEs occurred within 60 days after drug administration in the treatment group (8 cases, 32.00%), mainly involving TEAEs in mental system (7 cases, 28.00%) and nervous system (3 cases, 12.00%). The TEAEs occurred in the treatment group were relieved after withdrawal and/or symptomatic treatment. All TEAEs mainly occurred in nervous system (9 cases, 36.00%) and the mental system (5 cases, 20.00%) on the day of medication in the overdose group, among which 9 cases were completely improved, and 2 cases had sequelae after treatment.

Conclusion:

TEAEs caused by perampanel should be paid attention to, and medication education should be strengthened to avoid the occurrence of serious TEAEs and ensure the safety of clinical medication.

perampanel  /  treatment emergent adverse events  /  literature analysis
Ling DING, Li-hua LIU, Xing LUO, Fang HUANG, Xian-jing TANG, Fang-fang BI. Literature survey of perampanel-related treatment emergent adverse events[J]. Chinese Journal of New Drugs, 2023 , 32 (3) : 323 -328 .
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  • Online Date：2026-03-05
  • Published：2023-02-15
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History
  • Accepted：2022-03-14
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Affiliations
    1Department of Neurology, The Third Hospital of Changsha, Vascular Disease Control And Prevention Institute of Changsha, Changsha 410015, China
    2Department of Pharmacy, The Third Hospital of Changsha, Changsha 410015, China
    3Department of Neurology, Xiangya Hospital Central South University, Changsha 410008, China
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