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Camptothecin is a kind of quinoline alkaloid and is also a natural topoisomerase I inhibitor isolated from Camptotheca involucrata. After complexing with topoisomerase I-DNA, camptothecin prevents DNA replication and RNA synthesis, indicating an anti-tumor effect. Clinical studies have shown that camptothecin and its derivatives have good antitumor activity. However, the high toxicity and low bioavailability limited its clinical application. Novel drug delivery systems can make up the defects through enhancing the drug stability, bioavailability and targeting ability to improve the anti-tumor effect, which can help reduce the toxicity, and solve the problems of camptothecins to a certain extent. This paper analyzes and summarizes the research progress of camptothecin-based antitumor drug delivery systems in recent published literatures, in order to provide theoretical guidance and suggestion for the development of new preparations of camptothecins that meet the needs of clinical applications.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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