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Abrocitinib is a selective small-molecule Janus kinase-1 inhibitor. It was approved by the U.S. FDA for the treatment of adults with refractory, moderate-to-severe atopic dermatitis on January 14, 2022. It is the third oral JAK inhibitors for atopic dermatitis in the world, slightly later than baricitinib and upadacitinib developed by Incyte and AbbVie, respectively. Although the U.S. FDA label contains a black box warning against JAK inhibitors, safety data from clinical trials reveal a manageable tolerability and longer-term safety. This paper introduces the mechanism of action, dosage and administration, pharmacokinetics, clinical studies and safety evaluation of the drug.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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