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To prepare and optimize the formulation of resveratrol in situ floating gel using common gel materials with high safety and good biocompatibility, in order to obtain a temperature-sensitive gel that can float and continuously release drug in bladder and can be used for bladder perfusion in chemotherapy of bladder cancer.
The gel was prepared by cold dissolution method. Poloxam 407, Poloxam 188, sodium alginate, calcium carbonate and ammonium bicarbonate were used as main excipients. Gelling temperature and gelling time were selected as the indicators to optimize the quantity of poloxamer 407, poloxamer 188 and calcium carbonate in formulation by central combination-response surface method. Temperature sensitivity, floating performance and drug releasing performance of the optimized formulation were evaluated.
The optimal formulation was composed of resveratrol 30%, Poloxam 407 17.2%, Poloxam 188 5.5%, sodium alginate 0.15%, calcium carbonate 0.06%, ammonium bicarbonate 0.15%. The gelling temperature was 28~29 ℃ and the gelling time was 50 s. The drug were released from the gel in a way of diffusion for more than 48 days.
The resveratrol in situ floating gel had the property of continuous drug release for a long time in bladder. It can be used as an alternative form of bladder perfusion chemotherapy in the treatment of bladder cancer to improve patient compliance.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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