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To investigate the clinical efficacy and safety of apatinib in advanced gastric cancer with different blood supply.
The clinical data of 45 patients with advanced gastric cancer with different blood supply treated with apatinib were analyzed retrospectively. The patients with the difference of CT values between arterial phase and plain scan at the same level ≥40 HU were included in group A, ≥20 HU and <40 HU in group B, and <20 HU in group C. The therapeutic effects, serum carcinoembryonic antigen (CEA), carbohydrate antigen199 (CA199), survival and safety of the three groups were compared.
The objective remission rate and disease control rate of group A were significantly higher than those of group B and group C (P<0.05). After treatment, the CEA and CA199 of the three groups decreased significantly, and through pairwise comparison, the CEA and CA199 of the three groups ranked C, B and A from high to low. There was significant difference in PFS among the three groups (P<0.05). After pairwise comparison, the PFS of the three groups ranked A, B and C from high to low. The difference of adverse events among the three groups was not statistically significant (P>0.05).
The clinical efficacy of apatinib in rich blood supply advanced gastric cancer is better than that in lack of blood supply advanced gastric cancer. It has the same safety in rich blood supply advanced gastric cancer and lack of blood supply advanced gastric cancer.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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