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The scale of pediatric drug use in China exceeds 60 billion, but the quantity of pediatric drugs is limited and the variety is few, making the R&D and drug innovation is particularly necessary. Since children's esophagus is narrow, the respiratory tracts prematurely develop and the medication compliance is low, traditional drug dosage forms such as capsule, tablet, and decoction are easy to cause throat blockage, choking and even suffocation. According to the characteristics of children when taking medicine, the concept of oral gels has been put forward in foreign countries to improve the compliance of pediatric patients to take medicine and reduce the risk of aspiration. Based on the review of related literature in China and abroad, we conclude the common matrix and preparation methods of children's oral gels, summarize the characteristics and quality control methods of the dosage forms. Examples are given to show the general research situation of application both in China and abroad, as well as the situation of registration and listing, in order to promote the development of domestic pediatric oral gels, broaden the space of pediatric drugs' research and development, promote the exploitation of new pediatric drugs to protect children's health.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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