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To synthesize resveratrol analogues and investigate their anti-diabetic activity and related mechanism.
Using different substituted anilines and different substituted benzaldehydes as raw materials, resveratrol analogs were synthesized under ethanol reflux, and their protective effects on pancreatic β cells were tested under the stimulation of palmitic acid (PA). The anti-diabetic mechanism of the dominant compounds was explored.
Most of the compounds have protective effects on pancreatic β cells, and the compounds JA10 and JA12 have significant cytoprotective effects. Molecular mechanism studies showed that the compounds JA10 and JA12 reduced the generation of reactive oxygen, and inhibited the gene expression of inflammatory factors IL-1β and IL-6.
The resveratrol analogs JA10 and JA12 are potential antidiabetic new chemical entities.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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