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To investigate the therapeutic effect and safety of the extract of Qingxin Lianzi Decoction (QLD) on nephritis in rats.
The antibacterial activity of QLD extract against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa in vitro was determined by disk diffusion and double dilution methods. Pyelonephritis model induced by bacterial, adriamycin-induced glomerulonephritis model and IgA nephropathy model in rats were used to evaluate the therapeutic effect on nephritis in rats. The safety of QLD extract was preliminarily evaluated using the acute toxicity test in mice.
QLD extract had no obvious antibacterial activity against the three pathogenic bacteria in vitro, but it significantly reduced the contents of creatinine and urea nitrogen in serum, decreased the levels of urinary occult blood and urine protein in pyelonephritis rats. At the same time, the 8 g·kg-1 dose of QLD significantly reduced the contents of creatinine and urea nitrogen in serum, but had no significant effect on the kidney index and urine protein in glomerulonephritis rats. Moreover, the 8 g·kg-1 dose of QLD significantly reduced the level of urine protein in IgA nephropathy rats, but had no significant effect on creatinine, urea nitrogen and kidney index. The results of acute toxicity showed that the maximum dose of QLD extract is 48 g·kg-1, and no obvious toxicity and death were observed.
QLD extract has therapeutic effects on three experimental nephritis in rats.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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