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225Ac is one of the most promising radionuclides in alpha particle targeting therapy (targeted alpha therapy, TAT). The alpha particles produced by 225Ac decay have the characteristics of higher linear energy transfer, shorter tissue action distance, less side effects and so on. Therefore, TAT drugs such as small molecules and antibodies labeled with 225Ac have good application prospects in tumor treatment. This paper introduces the decay properties and sources of 225Ac, summarizes the commonly used chelating agents for 225Ac labeling, exemplifies the process of 225Ac labeling, and summarizes the application of 225Ac-labeled compounds in non-clinical and clinical research in the past three years. Finally, the challenges and prospects of 225Ac-labeled TAT drugs are analyzed, which provides a basis for the follow-up development of TAT drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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