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Research progress in cell membrane-modified biomimetic nano-drug delivery system in tumor photodynamic therapy
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Fu QI1, 2, Xian-chun DAI3, Yu-nan ZHAO2, Ai-xue LI1, 2, Yong-wei GU2, Ji-yong LIU2, 3
Chinese Journal of New Drugs | 2023, 32(16) : 1652 - 1659
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Chinese Journal of New Drugs | 2023, 32(16): 1652-1659
Research progress in cell membrane-modified biomimetic nano-drug delivery system in tumor photodynamic therapy
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Fu QI1, 2, Xian-chun DAI3, Yu-nan ZHAO2, Ai-xue LI1, 2, Yong-wei GU2, Ji-yong LIU2, 3
Affiliations
  • 1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 2Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai 200032, China
  • 3Department of Pharmacy, Shanghai Proton and Heavy Ion Center, Shanghai 201315, China
Published: 2023-08-30
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Photodynamic therapy (PDT) is a tumor treatment method that uses photosensitizers to convert oxygen into reactive oxygen species and stimulate multiple pathways to kill cells. PDT can break through some limitations in tumor treatment with the help of nano-drug delivery system, but it still cannot solve the key problem of poor biocompatibility of photosensitizers. The cell membrane-modified biomimetic nano-drug delivery system formed by introducing natural cell membrane into nano-drug delivery system can give full play to the low immunogenicity of the cell membrane, improve the biocompatibility of photosensitizers, and enhance the anti-tumor effect of PDT. This review focuses on the progress of nanoparticles modified with cancer cell membrane, red blood cell membrane, leukocyte membrane and hybrid cell membrane, and their applications in PDT against tumors. The advantages and disadvantages of every type of cell membrane-modified nanoparticles based on PDT have been summarized to provide reference for its clinical application.

cell membrane  /  nano-delivery system  /  photodynamic therapy  /  photosensitizer  /  tumor treatment
Fu QI, Xian-chun DAI, Yu-nan ZHAO, Ai-xue LI, Yong-wei GU, Ji-yong LIU. Research progress in cell membrane-modified biomimetic nano-drug delivery system in tumor photodynamic therapy[J]. Chinese Journal of New Drugs, 2023 , 32 (16) : 1652 -1659 .
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  • Online Date：2026-03-05
  • Published：2023-08-30
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  • Accepted：2022-08-25
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Affiliations
    1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    2Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai 200032, China
    3Department of Pharmacy, Shanghai Proton and Heavy Ion Center, Shanghai 201315, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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