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There are many kinds of drugs for insomnia, but the current hypnotics on the market cannot fully meet the clinical needs. As a new treatment for insomnia disorder, dural orexin receptor antagonist (DORAs) has a different mechanism of action from the traditional hypnotics, it can avoid a series of common side effects of traditional hypnotics and has a good safety profile. A newly developed dual orexin receptor antagonist, daridorexant, has been studied in a number of clinical studies in global, and data shows that it improves both the sleeping disorder at night and daily functions, with good safety feature. This review comprehensively summarizes the efficacy, safety, and clinical data of the dual orexin antibody antagonist daridorexant in various clinical trials.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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