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To compare the effects of methylphenidate sustained-release tablets and atomoxetine on sleep in patients with attention deficit hyperactivity disorder (ADHD).
A total of 70 patients with ADHD were enrolled and randomly divided into methylphenidate sustained-release tablets (MPH) and atomoxetine (ATX) treatment groups according to a random number table. Overnight polysomnography (PSG) was performed at baseline and the end of 2 and 6 weeks of medication.
Totally 48 patients with ADHD (23 in the MPH group, 65.7%; 25 in the ATX group, 71.4%) completed a total of 3 PSGs. At baseline, there was no significant difference in the values of each sleep parameter between the MPH group and the ATX group (P>0.05). At the end of 2 weeks, the sleep onset latency (SOL), REM onset latency (ROL) of the MPH group were longer than those of the ATX group; the REM time was shorter than that of the ATX group; the sleep efficiency SE (%) was worse than that of the ATX group, and the differences were statistically significant (P<0.05 for all). At 6 weeks, there was no significant difference in SOL, ROL, REM time and sleep efficiency SE (%) between the MPH group and the ATX group (P>0.05). The percentage of total sleep time (%TST) for N1, N2, N3 and R stages and the number of awakenings and wake after sleep onset WASO were not significantly different between the two groups (P>0.05).
Compared with the ATX group, the MPH group had a certain negative impact on the sleep condition of ADHD patients after 2 weeks of medication. There was no obvious difference in the effect on sleep between the two drugs after 6 weeks of continuous treatment. There was a certain correlation between the improvement of ADHD core symptoms and the improvement of sleep. Both MPH and ATX can be used as first-line drugs for treating ADHD patients with comorbid sleep problems.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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