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Non-alcoholic fatty liver disease (NAFLD) is a common chronic metabolic disease characterized by the accumulation of fat in the liver. The onset and progression of NAFLD are associated with a variety of metabolic abnormalities, including obesity, diabetes mellitus, and hyperlipidemia. Due to its high prevalence and risk worldwide, NAFLD has become an important issue in public health. However, to date, treatments for NAFLD are very limited, with no relevant drugs approved for marketing in Europe, America, or China and clinical trials of new drugs have gained no progress in recent years. This paper reviews the therapeutic targets, clinical research progress of new drugs, and new treatment strategies for NAFLD, in addition to summarizing the reasons for the high failure rate of NASH clinical trials and proposing corresponding solutions, aiming at providing ideas and reference for new drug development.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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