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To explore the value of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and lactate dehydrogenase (LDH) levels in evaluating the benefits of immunotherapy for lung small cell carcinoma with liver metastasis.
From November 2021 to August 2022, the clinical data of 56 patients diagnosed with pulmonary small cell lung carcinoma (SCLC) with liver metastases and treated with chemoradiotherapy combined with programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) inhibitors in our hospital were collected, and the follow-up was cut in September 2022. Blood routine examinations and LDH values before and after treatment of all patients were collected. The ROC curve was plotted and the optimal cutoff values of NLR, PLR and LDH were determined when the Youden index was maximum. The cases were divided into low indicator score group and high indicator score group respectively. Multivariate Cox regression analysis was used to screen independent predictors of survival after immunotherapy for SCLC liver metastasis.
The levels of NLR and PLR before treatment were related to the objective response rate (ORR) of patients receiving immunotherapy. Through univariate analysis of patients' progression free survival (PFS), we concluded that the risk factors of PFS in patients with liver metastasis were high NLR, high PLR and high LDH. The Cox proportional hazards model was used to analyze the risk factors obtained from the univariate analysis. The independent risk factors of PFS in patients with liver metastasis were high NLR and high LDH.
NLR, PLR and LDH can be used to predict the survival of SCLC after immunotherapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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