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Advances in the establishment and application of preclinical tumor models
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Han-lin XU1, 2, Jian-jun CHEN2, Fei ZHAO2, Yan CHANG2, Ying-qi LI1, 2, Man-qi LI2, Wei-wei HE2
Chinese Journal of New Drugs | 2023, 32(10) : 1021 - 1027
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Chinese Journal of New Drugs | 2023, 32(10): 1021-1027
Advances in the establishment and application of preclinical tumor models
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Han-lin XU1, 2, Jian-jun CHEN2, Fei ZHAO2, Yan CHANG2, Ying-qi LI1, 2, Man-qi LI2, Wei-wei HE2
Affiliations
  • 1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
  • 2China State Institute of Pharmaceutical Industry National, Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China
Published: 2023-05-30
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Cancer has always been a major disease that threatens human lives. Traditional treatment modalities cannot guarantee efficient killing of tumor cells and good prognosis after treatment, mainly because people do not have sufficient understanding of tumors and their microenvironment. In recent years, with the advancement of tumor research, the mechanism of tumorigenesis and the impact of tumors on human immune system have become hot topics of research. Various preclinical tumor models have been developed, including in vivo models represented by patient tumor-derived xenograft models (PDX) and in vitro models represented by organoid microarrays, which have different functions in preclinical tumor research and play important roles. As a convenient and effective tool, preclinical tumor models play an irreplaceable role in exploring tumor-immune system interactions, preclinical evaluation of anti-tumor drugs, and discovery of biomarkers for immunotherapy.

mouse tumor model  /  in vitro tumor model  /  tumor microenvironment  /  primary cell culture
Han-lin XU, Jian-jun CHEN, Fei ZHAO, Yan CHANG, Ying-qi LI, Man-qi LI, Wei-wei HE. Advances in the establishment and application of preclinical tumor models[J]. Chinese Journal of New Drugs, 2023 , 32 (10) : 1021 -1027 .
Year 2023 volume 32 Issue 10
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  • Online Date:2026-03-05
  • Published:2023-05-30
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  • Accepted:2022-05-27
Affiliations
    1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
    2China State Institute of Pharmaceutical Industry National, Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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