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To observe the protective effect of 6-O-methyl-catalpol on fructose-induced NAFLD in mice and its mechanism.
The mice were randomly divided into the control group and fructose-fed groups. After 4 weeks, the fructose-fed mice were further divided to 4 subgroups: model group, silybin group (35 mg·kg-1), 6-O-methyl-catalpol (30 mg·kg-1) group, and 6-O-methyl-catalpol (60 mg·kg-1) group. The drugs were administered by gavage qd for a period of 4 weeks. At the end of the treatment, the levels of ALT, AST, TC, TG, GLU, insulin and leptin were determined. The histopathological changes of liver were evaluated using HE staining. The fatty acid synthetase (FAS) and acetyl CoA carboxylase (ACC) protein expression in liver were measured using Western blot.
Compare with the model group, the elevated levels of AST, ALT, TC, TG, insulin, leptin and HOMA-IR significantly decreased in 6-O-methyl-catalpol groups (P<0.01). HE staining showed that the degree of hepatic steatosis was obviously ameliorated in 6-O-methyl-catalpol treatment groups. The protein expression levels of ACC and FAS were also significantly down-regulated in high 6-O-methyl-catalpol group (P<0.01).
6-O-methyl-catalpol exerts protective effect against NAFLD, which may be related to the improvement of insulin sensitivity and lipid metabolism.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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