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The signal pathway involved in the treatment of vascular cognitive impairment in rats by butylphthalide
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An-ge-shuo REN1, 3, Ya-ran GAO3, 4, Li-li XU2, 3, Ming HU5, 6
Chinese Journal of New Drugs | 2023, 32(9) : 902 - 905
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Chinese Journal of New Drugs | 2023, 32(9): 902-905
The signal pathway involved in the treatment of vascular cognitive impairment in rats by butylphthalide
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An-ge-shuo REN1, 3, Ya-ran GAO3, 4, Li-li XU2, 3, Ming HU5, 6
Affiliations
  • 1Graduate School of Hebei Medical University, Shijiazhuang 050011, China
  • 2Graduate School of Hebei North University, Zhangjiakou 075000, China
  • 3Department of Neurology, Hebei Provincial People's Hospital, Shijiazhuang 050051, China
  • 4Department of Neurology, Hebei Medical University, Shijiazhuang 050017, China
  • 5The First Hospital of Hebei Medical University, Shijiazhuang 050030, China
  • 6Xuanwu Hospital, Capital Medical University, Hebei Hospital, Shijiazhuang 050024, China
Published: 2023-05-15
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Vascular cognitive impairment (VCI) refers to a group of cognitive disorders caused by cerebrovascular disease or its related risk factors. The main clinical characteristics include cognitive dysfunction, with reduction of attention, memory and executive ability, and in severe cases, vascular dementia. DL-3-N-butylphthalein (NBP) is used to improve vascular cognitive impairment. It can increase the survival number of hippocampal neurons, promote synaptic formation, facilitate cerebrovascular regeneration, regulate cell apoptosis, thus exert a therapeutic effect of nerve function improvement. In recent years, more and more literatures was reported on the mechanism of NBP in the treatment of vascular cognitive impairment. This article will systematically elaborate the signal pathway and mechanism involved in the treatment of NBP that have been found so far, so as to provide reference and support for the further research on the prevention and treatment of vascular cognitive impairment.

DL-3-N-butylphthalide  /  vascular dementia  /  PI3k/Akt signal pathway  /  Shh/Ptch1 signal pathway  /  JNK/p38 MAPK signal pathway
An-ge-shuo REN, Ya-ran GAO, Li-li XU, Ming HU. The signal pathway involved in the treatment of vascular cognitive impairment in rats by butylphthalide[J]. Chinese Journal of New Drugs, 2023 , 32 (9) : 902 -905 .
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Year 2023 volume 32 Issue 9
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  • Online Date：2026-03-05
  • Published：2023-05-15
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History
  • Accepted：2023-02-17
Affiliations
    1Graduate School of Hebei Medical University, Shijiazhuang 050011, China
    2Graduate School of Hebei North University, Zhangjiakou 075000, China
    3Department of Neurology, Hebei Provincial People's Hospital, Shijiazhuang 050051, China
    4Department of Neurology, Hebei Medical University, Shijiazhuang 050017, China
    5The First Hospital of Hebei Medical University, Shijiazhuang 050030, China
    6Xuanwu Hospital, Capital Medical University, Hebei Hospital, Shijiazhuang 050024, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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