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Progress of anti-hepatic fibrosis medicines in clinical trials
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Wei-ping NIU, Hong-wei HE, Ju-xian WANG, Yu-cheng WANG
Chinese Journal of New Drugs | 2023, 32(5) : 492 - 500
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Chinese Journal of New Drugs | 2023, 32(5): 492-500
Progress of anti-hepatic fibrosis medicines in clinical trials
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Wei-ping NIU, Hong-wei HE, Ju-xian WANG, Yu-cheng WANG
Affiliations
  • Institute of Medical Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Published: 2023-03-15
Outline
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Hepatic fibrosis is a pathological consequence of the development of chronic liver disease. Previous research found that hepatic fibrosis is a reversible disease. If effective treatment can be given to hepatic fibrosis stage, it will be of great significance for the treatment of chronic hepatitis, the prevention of cirrhosis and liver cancer. There are limited medicines approved for the treatment of hepatic fibrosis, most of which are still in clinical trials. Anti-hepatic fibrosis medicines that are in clinical trial stage include CC chemokine receptor 2/5 antagonist, farnesoid X receptor agonist, ASK1 inhibitor, etc. This article mainly introduces the mechanism and research progress of anti-hepatic fibrosis medicines in clinical trial.

anti-hepatic fibrosis  /  reversible disease  /  clinical trial
Wei-ping NIU, Hong-wei HE, Ju-xian WANG, Yu-cheng WANG. Progress of anti-hepatic fibrosis medicines in clinical trials[J]. Chinese Journal of New Drugs, 2023 , 32 (5) : 492 -500 .
Year 2023 volume 32 Issue 5
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  • Online Date:2026-03-05
  • Published:2023-03-15
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  • Accepted:2022-07-04
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    Institute of Medical Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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