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Quercetin enteric nanoparticles were prepared by electrostatic spray technology, and the preparation process was optimized by central composite design-response surface methodology.
The ethanol solution of quercetin/Eudragit L100 (1∶1, w/w) was prepared using Eudragit L100 as an enteric coating material. The effects of solution concentration, electrostatic spray voltage, spraying speed and receiving distance on the particle size were investigated. On the basis of single factor test results, the optimal process parameters were selected by central composite design-response surface methodology. The nanoparticles were evaluated by scanning electron microscope, X-ray powder diffraction and differential thermal analysis. The equilibrium solubility and dissolution of quercetin nanoparticles were determined in the solution of pH 1.2 and pH 6.8.
The optimum preparation conditions are Quercetin/Eudragit L100 concentration of 0.48%, spray voltage of 29.9 kV, spray speed of 0.44 mL·h-1 and receiving distance of 23.18 cm. The prepared enteric nanoparticles were spherical with an average diameter of (251.1±7.8) nm. The results of X-ray powder diffraction and differential thermal analysis showed that quercetin was amorphous in nanoparticles. The equilibrium solubilities of quercetin enteric nanoparticles were 1.069 and 6.827 μg·mL-1 in pH 1.2 and pH 6.8 solution, respectively, and the dissolutions of quercetin enteric nanoparticles at 2 h were 15.1% and 83.9% in pH 1.2 and pH 6.8 solution, respectively.
Quercetin enteric nanoparticles prepared by electrostatic spraying had a good enteric effect.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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