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Oliceridine: a new drug for the treatment of moderate to severe acute pain in adults
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Xi-min WU, Xiao-jing ZHANG, Mi FENG, Hui-li CHANG
Chinese Journal of New Drugs | 2023, 32(5) : 469 - 475
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Chinese Journal of New Drugs | 2023, 32(5): 469-475
Oliceridine: a new drug for the treatment of moderate to severe acute pain in adults
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Xi-min WU, Xiao-jing ZHANG, Mi FENG, Hui-li CHANG
Affiliations
  • The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511500, China
Published: 2023-03-15
Outline
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Oliceridine is a G-protein-biased μ-opioid receptor agonist. It was approved by the U.S. FDA for the treatment of moderate to severe acute pain in adults by intravenous injection on August 7, 2020. Clinical studies have shown that oliceridine has a favorable analgesic efficacy which is noninferior than morphine with a lower risk of opioid-related adverse events than conventional opioids at the same time. This review focuses on the mechanism of action, pharmacokinetics, pharmacodynamics, clinical studies and safety evaluation of oliceridine.

oliceridine  /  moderate to severe acute pain  /  μ-opioid receptor agonist  /  G protein-biased agonist
Xi-min WU, Xiao-jing ZHANG, Mi FENG, Hui-li CHANG. Oliceridine: a new drug for the treatment of moderate to severe acute pain in adults[J]. Chinese Journal of New Drugs, 2023 , 32 (5) : 469 -475 .
Year 2023 volume 32 Issue 5
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  • Online Date:2026-03-05
  • Published:2023-03-15
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  • Accepted:2022-07-04
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    The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511500, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
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Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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