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Mechanism of Polygonatum in the prevention and treatment of Alzheimer's disease based on network pharmacology
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Wei MA1, 2, 3, Yun-dong YIN1, 2, 3, Hao-ling ZHANG1, 2, 3, Wei-yi CAO1, 2, 3, Rui GAO1, 2, 3
Chinese Journal of New Drugs | 2023, 32(4) : 372 - 378
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Chinese Journal of New Drugs | 2023, 32(4): 372-378
Mechanism of Polygonatum in the prevention and treatment of Alzheimer's disease based on network pharmacology
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Wei MA1, 2, 3, Yun-dong YIN1, 2, 3, Hao-ling ZHANG1, 2, 3, Wei-yi CAO1, 2, 3, Rui GAO1, 2, 3
Affiliations
  • 1Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
  • 2NMPA for Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing 100091, China
  • 3National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091, China
Published: 2023-02-28
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Objective:

To explore the main active components, potential targets and mechanisms of Polygonatum in the treatment of Alzheimer's disease (AD) by using network pharmacological techniques and methods.

Methods:

The active components of Polygonatum were screened in TCMSP. AD-related targets were retrieved from GeneCards database, TTD database and DrugBank database. Cytoscape 3.7.2 software was used to establish the "yellow essence-component-target" network, which was imported into STRING database to obtain the target PPI network. Key genes were screened using "CytoHubba" function, and GO biological process and KEGG pathway enrichment analysis were performed.

Results:

β-Sitosterol, baicalin, diosgenin and other active components in Polygonatum may exert an effect of prevention and treatment of AD through AKT1, CASP3, TP53, VEGFA, HIF1, mTOR and other key gene targets to regulate neurodegenerative pathways, including various diseases, PI3K-Akt signaling pathway, MAPK signaling pathway, and apoptosis signaling pathway.

Conclusion:

Polygonatum may regulate and integrate multi-components, multi-targets and multi-pathways to achieve prevention and treatment of AD.

Polygonatum  /  Alzheimer's disease  /  network pharmacology
Wei MA, Yun-dong YIN, Hao-ling ZHANG, Wei-yi CAO, Rui GAO. Mechanism of Polygonatum in the prevention and treatment of Alzheimer's disease based on network pharmacology[J]. Chinese Journal of New Drugs, 2023 , 32 (4) : 372 -378 .
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  • Online Date：2026-03-05
  • Published：2023-02-28
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  • Accepted：2022-11-22
Funding
Affiliations
    1Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
    2NMPA for Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing 100091, China
    3National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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