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Meta-analysis of the efficacy and safety of ginkgo biloba preparations for treating depression
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Hong-yang GAO, Fang LU, Yang ZHAN, Qing-na LI, Wei-yi CAO, Ming-yue SUN
Chinese Journal of New Drugs | 2023, 32(4) : 379 - 385
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Chinese Journal of New Drugs | 2023, 32(4): 379-385
Meta-analysis of the efficacy and safety of ginkgo biloba preparations for treating depression
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Hong-yang GAO, Fang LU, Yang ZHAN, Qing-na LI, Wei-yi CAO, Ming-yue SUN
Affiliations
  • Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
Published: 2023-02-28
Outline
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Objective:

To systematically evaluate the efficacy and safety of ginkgo biloba preparation combined with western medicines in the treatment of depression.

Methods:

Randomized controlled trials (RCTs) were electronically retrieved from CNKI, Wanfang Data, VIP, CBM, Pubmed and Cochrane Library according to the preset inclusion criteria and exclusion criteria. A total of 242 articles were retrieved. Through reading topics, abstracts, and full texts, 12 articles that met the inclusion and exclusion criteria were finally included for the analysis. The data extraction and Meta-analysis were conducted by using RevMan 5.3 software.

Results:

The clinical efficacy of ginkgo biloba preparation combined with western medicines in the treatment of depression was superior to the western medicine routine treatment group, OR=2.48, 95%CI (1.77, 3.45), P<0.000 01. At the same time, the combined application of Ginkgo biloba extract could reduce the HAMD scale score and improve depressive symptoms, MD=-3.22, 95%CI (-4.25, -2.19), P<0.000 01.

Conclusion:

Compared with the western medicine routine treatment group, the ginkgo biloba preparation treatment can improve depressive symptoms, lower the HAMD score, and reduce the adverse reactions of western medicines.

depressive disorder  /  ginkgo biloba preparation  /  Meta-analysis
Hong-yang GAO, Fang LU, Yang ZHAN, Qing-na LI, Wei-yi CAO, Ming-yue SUN. Meta-analysis of the efficacy and safety of ginkgo biloba preparations for treating depression[J]. Chinese Journal of New Drugs, 2023 , 32 (4) : 379 -385 .
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  • Online Date：2026-03-05
  • Published：2023-02-28
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History
  • Accepted：2023-01-09
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    Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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