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To provide recommendations for clinicians on rational use of Chinese patent medicine for treatment of heart failure, the study was conducted by systematically collecting and analyzing clinical randomized controlled trials (RCTs). Based on three international electronic databases (PubMed, Embase and Cochrane library) and three Chinese literature databases (Chinese Journal Full Text Database, Wanfang Medical Database and Chinese Science and Technology Journal Database (Weipu)), all relevant RCTs from the beginning of the establishment of each database to July 1, 2022 were included, a total of 83 proprietary Chinese medicines were retrieved, and finally 15 proprietary Chinese medicines were chosen to be recommended for treatment of heart failure, including 7 injections and 8 oral proprietary Chinese medicines. The basic information, sample size, intervention and outcome indicators of the 15 proprietary Chinese medicines were compared and analyzed, and the quality of evidence for the efficacy of the included proprietary Chinese medicines was evaluated using the GRADE classification method to assess their efficacy and safety on heart failure with reduced ejection fraction (HFrEF), heart failure with preserved ejection fraction (HFpEF) and acute heart failure (AHF). Combined with the evidence-based medicine approach, a comprehensive evaluation of 15 proprietary Chinese medicines currently in use and with sufficient evidence for the treatment of heart failure were conducted, with the intention to provide some basis for clinicians to use proprietary Chinese medicines rationally.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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