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Objective: To evaluate the anti-platelet aggregation effect and advantages of Quansanqi tablets (PSQ), an innovative new drug of Panax notoginseng. Methods: Human platelet-rich plasma and washed platelets were used to detect the platelet aggregation rate and calcium ion concentration induced by different platelet activators; rat platelet-rich plasma was used to compare the platelet aggregation rate induced by ADP in PSQ and Panax notoginseng extract; gastric bleeding model rats were established by injecting 80% ethanol to investigate the effects of PSQ and aspirin on fecal occult blood; the hemostatic effect of PSQ was observed by mouse and rat coagulation test. Results: PSQ could dose-dependently inhibit ADP, thrombin, U46619, collagen and reduce anti-CD9-induced human platelet aggregation rate (P<0.01) and Ca2+ release (P<0.05 or P<0.01); it could inhibit ADP-induced rat platelet aggregation rate (P<0.01), with significantly better effect than Panax notoginseng extract. PSQ could reduce the fecal occult blood grade in gastric bleeding model rats (P<0.05), while aspirin could not (P>0.05); it could also significantly shorten the coagulation time in mice and APTT time in rats, indicating certain hemostatic effect. Conclusion: PSQ has significant anti-platelet aggregation effect through multiple ways with multiple action targets, and can also reduce the risk of bleeding because of its excellent hemostatic effect, which is a safe and effective new antiplatelet drug.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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