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Objective: To observe the effect of Xiangpishengji Ointment on the wound surface model of small Bama pigs, preliminarily observe the effect of Xiangpishengji Ointment on the VEGF-Notch signaling pathway in the wound surface of experimental pigs, compare the difference in wound healing between experimental pigs and rodents, and explore the rationality of selecting experimental pigs for the development of wound surface model. Methods: A total of 48 sores were prepared on the back of 4 small Bama pigs and divided into 2 groups, namely the Conwell hydrogel group and the Xiangpishengji Ointment group. Photos were taken on the 0, 7 and 14 days after surgery. Image J software was used to measure the wound area, calculate the wound healing rate, record the wound healing time, and observe the pathological changes with HE staining. The expression of VEGF-Notch signaling pathway related factors in wound tissue was detected by immunohistochemistry. Results: Xiangpishengji Ointment could promote the wound healing of experimental pigs, improve the wound healing rate, shorten the healing time, and promote the expression of VEGF-Notch signaling pathway related factors. Conclusion: Xiangpishengji Ointment can promote the healing of small Bama pig wound model, which may be related to the influence on VEGF-Notch signaling pathway. Experimental pigs are more similar to humans than rats in physiological and pathological aspects, and may become an accurate model for wound healing exploration in the future.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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