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Review of in vitro potency assays for CAR-T cell therapy products
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Zi-qiang WANG, Can WANG, Gao-min LI, Xu-hua DUAN, Hong SHAO
Chinese Journal of New Drugs | 2023, 32(18) : 1837 - 1842
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Chinese Journal of New Drugs | 2023, 32(18): 1837-1842
Review of in vitro potency assays for CAR-T cell therapy products
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Zi-qiang WANG, Can WANG, Gao-min LI, Xu-hua DUAN, Hong SHAO
Affiliations
  • Shanghai Institute for Food and Drug Control/National Medical Products Administration Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies/Shanghai Quality Inspection and Testing Center for Innovative Biological Products, Shanghai 201203, China
Published: 2023-09-30
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As the use of cell therapy products such as chimeric antigen receptor T cells (CAR-T) is getting matured, there has been an increasing interest in the methods used to test the quality of cell therapy products. In vitro viability assay is an important method for evaluating the effectiveness of cell therapy products and is also widely used in the product release process because of its simplicity and rapidity. In this paper, we review the in vitro potency determination methods for cell therapy products such as CAR-T from the perspective of both effector cells and target cells.

CAR-T cells  /  potency assay  /  quality control  /  cell killing  /  cytokine secretion
Zi-qiang WANG, Can WANG, Gao-min LI, Xu-hua DUAN, Hong SHAO. Review of in vitro potency assays for CAR-T cell therapy products[J]. Chinese Journal of New Drugs, 2023 , 32 (18) : 1837 -1842 .
Year 2023 volume 32 Issue 18
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  • Online Date:2026-03-05
  • Published:2023-09-30
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  • Accepted:2023-03-13
Affiliations
    Shanghai Institute for Food and Drug Control/National Medical Products Administration Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies/Shanghai Quality Inspection and Testing Center for Innovative Biological Products, Shanghai 201203, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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