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An updated review on dosage regimen and therapeutic drug monitoring of caffeine for treating apnea of prematurity
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Hao-ran DAI1, 2, Jia-yi LONG1, 2, Hong-li GUO1, Ya-hui HU1, Xuan-sheng DING2, Jing XU1, Rui CHENG3, Feng CHEN1
Chinese Journal of New Drugs | 2023, 32(18) : 1858 - 1865
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Chinese Journal of New Drugs | 2023, 32(18): 1858-1865
An updated review on dosage regimen and therapeutic drug monitoring of caffeine for treating apnea of prematurity
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Hao-ran DAI1, 2, Jia-yi LONG1, 2, Hong-li GUO1, Ya-hui HU1, Xuan-sheng DING2, Jing XU1, Rui CHENG3, Feng CHEN1
Affiliations
  • 1Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, China
  • 2School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China
  • 3Neonatal Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing 210008, China
Published: 2023-09-30
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Caffeine is the drug of choice for the treatment of apnea of prematurity. Although it has been used abroad for nearly 50 years, it has only begun to be widely used in China in recent years. There is still no consensus on the timing of caffeine initiation and discontinuation at home and abroad up to now. The efficacy and safety of caffeine under the standard-dose regimen have been confirmed, but the apnea symptoms of some preterm infants are still poorly controlled. The high-dose regimen is more effective, but the potential adverse effects are still worrisome. In addition, the necessity for the therapeutic drug monitoring of caffeine remains debatable since the effective blood concentration range is still controversial. Therefore, the pharmacokinetic characteristics of caffeine in premature infants, as well as the efficacy, safety, and effective blood concentration range under different dosage regimens were summarized. Of note, the research progress of the therapeutic drug monitoring and dose regimen optimization of caffeine were also discussed.

caffeine  /  apnea of prematurity  /  dosage regimen  /  blood concentration  /  therapeutic drug monitoring
Hao-ran DAI, Jia-yi LONG, Hong-li GUO, Ya-hui HU, Xuan-sheng DING, Jing XU, Rui CHENG, Feng CHEN. An updated review on dosage regimen and therapeutic drug monitoring of caffeine for treating apnea of prematurity[J]. Chinese Journal of New Drugs, 2023 , 32 (18) : 1858 -1865 .
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  • Online Date：2026-03-05
  • Published：2023-09-30
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  • Accepted：2022-12-26
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    1Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, China
    2School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China
    3Neonatal Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing 210008, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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