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Fumagillin is a natural insoluble antibiotic isolated and purified from the liquid fermentation medium of Aspergillus fumigatus. Fumagillin and its derivatives have been found to have a variety of biological activities such as anti-tumor, anti-obesity and anti-microsporidiosis, so they are widely used in the field of medicine. The molecular structure properties, biological activity, application and mechanism of action of fumagillin and its several common derivatives based on C6 site modification, such as fumagillin B, TNP-470, CKD-732 and PPI-2458 are reviewed in this article, and the separation and purification process, activity research and application prospect are prospected in order to provide reference for the further application of low toxic fumagillin and its derivatives in clinical practice and research.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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