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Research progress of the mechanism, metabolism and distribution of vigabatrin
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Qiang ZHENG1, 2, 3, Min FAN1, 2, 3, Jin-fang GE1, 2, 3
Chinese Journal of New Drugs | 2023, 32(13) : 1351 - 1357
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Chinese Journal of New Drugs | 2023, 32(13): 1351-1357
Research progress of the mechanism, metabolism and distribution of vigabatrin
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Qiang ZHENG1, 2, 3, Min FAN1, 2, 3, Jin-fang GE1, 2, 3
Affiliations
  • 1School of Pharmacy, Anhui Medical University, Hefei 230032, China
  • 2Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Hefei 230032, China
  • 3Anhui Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei 230032, China
Published: 2023-07-15
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The antiepileptic drug vigabatrin (VGB) is a selective and irreversible inhibitor of γ-aminobutyric acid transaminase, which can inhibit the abnormal electrical activity in brain via increasing the concentration of inhibitory neurotransmitter γ-aminobutyric acid (GABA). The clinical indications of VGB include infantile spasms and refractory partial seizure epilepsy, acting as a single treatment or an adjuvant treatment, respectively. Visual field loss is the main adverse reaction of VGB that limits its clinical application. Increasing evidence has demonstrated that, apart from acting on the GABA ergic system, VGB exerts an antiepileptic effect via regulating the metabolic changes of tissue endogenous substances including β-alanine, aspartic acid, ornithine, as well as the function of mechanistic target of rapamycin (mTOR) signalling pathway. In this article, we mainly review the progress of the studies focusing on mechanism, metabolism, and distribution of VGB, which will be helpful to understand the pharmacodynamics and toxic and side effects of VGB in depth.

vigabatrin  /  γ-aminobutyric acid  /  infantile spasms  /  distribution  /  metabolism
Qiang ZHENG, Min FAN, Jin-fang GE. Research progress of the mechanism, metabolism and distribution of vigabatrin[J]. Chinese Journal of New Drugs, 2023 , 32 (13) : 1351 -1357 .
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  • Online Date：2026-03-05
  • Published：2023-07-15
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  • Accepted：2022-10-25
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    1School of Pharmacy, Anhui Medical University, Hefei 230032, China
    2Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Hefei 230032, China
    3Anhui Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei 230032, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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