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The health decision will be impacted by the selection of different comparators that influence the results of the comparative effectiveness and incremental cost-effectiveness analysis. With the application of health technology assessment in assistent of health decision-making, the selection of comparators has gradually received stakeholders' attention. Focusing on the comparators selection, this study systematically reviews the health technology assessment guidelines and comparator selection guidelines published by seven countries and regions including China Taiwan, Japan, the United Kingdom, Germany, Canada, Australia, the United States and international organizations based on a literature review. Meanwhile, taking the selection of comparators as an example in the health technology evaluation report of chimeric antigen receptor T-cell (CAR-T) immunotherapy therapies when applying for medical insurance access in different countries, the international experience is summarized from the selection process, criteria, methods, usage and other dimensions. To deal with the current issues discussed in this study, the decision-making departments and stakeholders need to determine the comparators before the beginning of the evaluation, establish a two-way communication and feedback mechanism, determine the selection criteria and methods based on different decision-making purposes and uses, and select flexible response options for special circumstances, so as to provide reference for optimizing the selection of comparators in drug value evaluation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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