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To study the mechanism of action of DL-3-N-butylphthalide (NBP) on cerebral small vessel disease in diabetic rats based on Nrf2/HO-1 signaling pathway.
The successfully modeled diabetes rats with cerebrovascular disease were randomly divided into NBP treatment group and model group. The water maze test was carried out. After taking the materials, paraffin sections were stained, dehydrated and sealed. The histological structure of the rat cerebral cortex and the histopathological changes of neurons in this area were observed under a microscope. The expressions of Nrf2 and HO-1 protein in Nrf2/HO-1 signal pathway of brain tissue were detected by Western blot.
Compared with the model group, the escape latency of the rats in the NBP-treated group was shortened gradually on the 1st-4th day in the water maze test. Compared with the model group, the cells of brain tissue in the NBP-treated group were arranged regularly, the nuclei were full and round, and the pyknosis was decreased. Western blot analysis showed that Nrf2 and HO-1 protein expression in the brain tissue of rats treated with NBP was higher than that of the model group.
Nrf2 and HO-1 were increased in the brain tissue of NBP-treated rats, and NBP may play a protective role in the brain by up-regulating the expression of anti-oxidative stress protein.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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