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Research progress in procyanidins for the prevention and treatment of central nervous system degenerative diseases
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Zi-meng YAO1, Lei CHEN1, Xiao-rong SUN1, Jie HUANG1, Shu-ying DONG1, 2
Chinese Journal of New Drugs | 2023, 32(14) : 1432 - 1437
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Chinese Journal of New Drugs | 2023, 32(14): 1432-1437
Research progress in procyanidins for the prevention and treatment of central nervous system degenerative diseases
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Zi-meng YAO1, Lei CHEN1, Xiao-rong SUN1, Jie HUANG1, Shu-ying DONG1, 2
Affiliations
  • 1Department of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu 233030, China
  • 2Basic and Clinical Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical College, Bengbu 233030, China
Published: 2023-07-30
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In recent years, with the change of people's living standards and the increasingly serious aging phenomenon, the incidence of degenerative diseases of the central nervous system is increasing. Due to the unknown etiology, such diseases seriously affect the quality of life of patients and increase the economic burden of the society and patients' families. Therefore, finding a new drug to treat this kind of disease has become a research hotspot. Procyanidins (PCs) have antioxidant, anti-apoptotic, anti-inflammatory, anticancer and neuroprotective effects, suggesting that PCs have multi-target pharmacological effects. Because of this, PCs have attracted extensive attention as natural antioxidants and have been applied in the treatment of animal models of nervous system diseases. Based on the current status of research on the pharmacological effects of PCs by domestic and foreign scholars, this paper reviews the research progress in the role and mechanism of PCs in the prevention and treatment of degenerative diseases of central nervous system and puts forward the view that PCs may be related to the inhibition of iron death in the treatment of degenerative diseases of central nervous system.

procyanidins  /  degenerative diseases of central nervous system  /  pharmacological actions  /  multi-target effect
Zi-meng YAO, Lei CHEN, Xiao-rong SUN, Jie HUANG, Shu-ying DONG. Research progress in procyanidins for the prevention and treatment of central nervous system degenerative diseases[J]. Chinese Journal of New Drugs, 2023 , 32 (14) : 1432 -1437 .
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  • Online Date：2026-03-05
  • Published：2023-07-30
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  • Accepted：2022-08-11
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Affiliations
    1Department of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu 233030, China
    2Basic and Clinical Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical College, Bengbu 233030, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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