PDF
Full
Outline
To analyze the clinical efficacy of rituximab by comparing the changes of clinical manifestations, immunological features, imaging tests and human lipopolysaccharids-binding protein (LBP) before and after rituximab treatment in patients with lupus mesenteric vasculitis (LMV).
A total of 10 patients diagnosed with secondary LMV of systemic lupus erythematosus (SLE) in the Department of Rheumatology and Immunology of Peking University People's Hospital from January 2011 to May 2023 who were treated with rituximab were enrolled. Their clinical characteristics, laboratory results, efficacy and prognosis data were analyzed, and the level of intestinal injury marker LBP before and after treatment was analyzed.
The clinical symptoms of 10 LMV patients were significantly improved after rituximab treatment, abdominal pain lessened or disappeared (P=0.003), gastrointestinal wall thickening and edema alleviated or disappeared (P=0.000), intestinal obstruction/perforation relieved (P=0.025), IgG declined (P=0.032), complement 3 rebounded (P=0.047), the percentage of B lymphocytes decreased (P=0.022), and SLEDAI scores decreased (P=0.005). LMV remission rate was 100%, while the recurrence rate was 10%. LBP concentration decreased significantly after rituximab treatment [(8.94±6.37) μg·mL-1 vs (2.89±3.21) μg·mL-1, P=0.04].
Rituximab combined with glucocorticoid therapy can effectively improve serum immunological features, imaging tests and intestinal damage in patients with lupus mesenteric vasculitis, and has good clinical effect. Human lipopolysaccharide-binding protein is expected to be an index for evaluating and monitoring intestinal injury in lupus mesenteric vasculitis.
PDF
31
14
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
