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To evaluate the possibility of hepatitis B reactivation in patients with hepatitis B infection-associated rheumatoid arthritis who were treated with TNF inhibitors.
Literature search method and inclusion and exclusion criteria were established, then the databases were searched, literature meeting inclusion criteria were collected, and relevant data was extracted for analysis.
A total of 14 studies involving 534 HBV-related rheumatoid arthritis patients were included. The overall comprehensive hepatitis B reactivation rate was 0.017 5 [95%CI: 0.005 4, 0.034 0], I2=67%, P<0.01. In the subgroup analysis, the reactivation rate of hepatitis B using glucocorticoids was 0.067 6 [95%CI: 0.039 6, 0.101 2], I2=89%, P<0.01. The reactivation rate of hepatitis B without glucocorticoids was 0.045 7 [95%CI: 0.016 4, 0.084 6], I2=69%, P<0.01.
The employment of TNF inhibitors in patients with HBV-related rheumatoid arthritis had a certain rate of hepatitis B reactivation. In the subgroup analysis, the rate of hepatitis B reactivation in the target population showed a distinct regional distribution, and the rate of hepatitis B reactivation in the glucocorticoid-using subgroup was higher than that in the glucocorticoid-not subgroup.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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