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Analysis of clinical trials registration for ankylosing spondylitis based on data on the web of ClinicalTrials.gov
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Li-na BAI1, Hua-li MIAO2, Wan-ling LI3, Yan-bing SU4, Xiu-ying FAN5, Li-yun ZHANG5
Chinese Journal of New Drugs | 2023, 32(22) : 2284 - 2292
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Chinese Journal of New Drugs | 2023, 32(22): 2284-2292
Analysis of clinical trials registration for ankylosing spondylitis based on data on the web of ClinicalTrials.gov
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Li-na BAI1, Hua-li MIAO2, Wan-ling LI3, Yan-bing SU4, Xiu-ying FAN5, Li-yun ZHANG5
Affiliations
  • 1Department of Rheumatology and Immunology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
  • 2Nursing Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
  • 3General Medical Department, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430033, China
  • 4Science and Research Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
  • 5Drug Clinical Trial Institution, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
Published: 2023-11-30
Outline
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Objective:

To analyze all clinical trials of ankylosing spondylitis (AS) up to December 31, 2022, so as to provide information reference for clinical studies related to AS drug treatment.

Methods:

The website ClinicalTrials.gov was searched, then the items of the retrieved trials were described and analyzed.

Results:

There were 392 clinical trials of AS, with 59 countries/regions participating in the world, and the top three were the United States, China, and Germany. The primary objective of the trials was treatment (n=187), followed by prevention (n=9). Nearly two-thirds of the trials excluded children, and 97% of the trials were not gender restricted. Most studies were designed to be randomized, parallel-assigned, and unblinded. The largest number of interventional trials involved biological agents (n=201), followed by chemical agents (n=65), and a small number of trials (n=3) also investigated the therapeutic effects of stem cells.

Conclusion:

Most of the clinical trials of AS registered on ClinicalTrials.gov are randomized, parallel-assigned, unblinded interventional trials based on therapeutic purposes. The participating countries and sponsors are mostly in the United States, and a majority of the trials are funded by pharmaceutical companies. At the same time, new biological agents targeting different targets have gradually become the mainstream, bringing new opportunities for the treatment of AS.

ankylosing spondylitis  /  ClinicalTrials.gov  /  trial registration  /  drug research  /  biological agents
Li-na BAI, Hua-li MIAO, Wan-ling LI, Yan-bing SU, Xiu-ying FAN, Li-yun ZHANG. Analysis of clinical trials registration for ankylosing spondylitis based on data on the web of ClinicalTrials.gov[J]. Chinese Journal of New Drugs, 2023 , 32 (22) : 2284 -2292 .
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Year 2023 volume 32 Issue 22
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  • Online Date：2026-03-05
  • Published：2023-11-30
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History
  • Accepted：2023-08-21
Affiliations
    1Department of Rheumatology and Immunology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
    2Nursing Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
    3General Medical Department, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430033, China
    4Science and Research Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
    5Drug Clinical Trial Institution, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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