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To review the application and recent research progress of phosphodiesterase 4 (PDE4) inhibitors in rheumatic autoimmune diseases.
Through a review of recent relevant literature and guidelines, we explored the latest research progress of PDE4 inhibitors in rheumatic autoimmune diseases such as psoriatic arthritis, Behçet's syndrome, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and systemic sclerosis, focusing on their clinical efficacy, safety, and mechanisms of action.
PDE4 inhibitors demonstrated significant clinical efficacy in rheumatic autoimmune diseases, often accompanied by manageable adverse reactions like nausea and diarrhea.
PDE4 inhibitors are safe and effective drugs for treating rheumatic autoimmune illnesses and can improve the quality of life. They hold promising prospects for clinical applications.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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