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Clinical trials is a scientific experimental activity that needs thorough plan and strict execution. Investigators often expect to complete the trial according to the study plan. However, due to the uncertainty of disease mechanisms, the diversity of patients, and the complexity of interventions, trials usually cannot be executed exactly according to the established protocols. A comprehensive review of the implementation of registered clinical trials reveals that such situations are not uncommon and commonly include: the aim of the clinical trials is apparent inability to complete thus requiring termination of the trials; unexpected events, such as adverse reactions, policy changes, etc., leading to suspend the trial and adjust the trial protocol. However, research on this issue is limited, and there is no definite answer on the scientific understanding, reason analysis, and plan design. In this paper, we comprehensively review the factors related to the suspension and termination of clinical trials and try to propose a solution.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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