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Salt-inducible kinases (SIKs) belong to the AMP-activated protein kinase (AMPK) family, which mainly regulates the cytosolic-cytoplasmic distribution of cAMP-response element binding protein transcriptional coactivators (CRTCs). They exert regulatory effect on the synthesis of CRTC-CREB complexes, which indirectly affect the transcription and expression of CREB target genes and various physiological processes, such as energy metabolism, cell cycle progression and apoptosis. Previous researches related to SIKs have focused on peripheral system diseases, including tumors, hypertension and gluconeogenesis. In recent years, increasing studies have begun to explore the link between SIKs and central nervous system diseases with abnormal levels of SIKs present in diseases such as depression, sleep disturbance, epilepsy and Alzheimer's disease. It suggests that dysregulation of SIKs signaling is involved in the pathological processes of these diseases and has the potential to become new therapeutic targets in these diseases. This article reviews the role and regulatory mechanisms of SIKs in depression, sleep disturbance and other neurological diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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