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Progress in research on side effects of FDA listed weight-loss drugs and considerations on their safety
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Wei ZHOU1, Peng MA2, Tian-shu XU2, Li ZHANG2, 3, Guan-hua DU2, Gui-fen QIANG2
Chinese Journal of New Drugs | 2023, 32(20) : 2113 - 2120
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Chinese Journal of New Drugs | 2023, 32(20): 2113-2120
Progress in research on side effects of FDA listed weight-loss drugs and considerations on their safety
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Wei ZHOU1, Peng MA2, Tian-shu XU2, Li ZHANG2, 3, Guan-hua DU2, Gui-fen QIANG2
Affiliations
  • 1Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China
  • 2Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China
  • 3Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010107, China
Published: 2023-10-30
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This article reviewed the reports of adverse reactions of 17 weight-loss drugs approved by the FDA since 1887 during the clinical trials and after their marketing, including six that are still on the market and 11 that have been withdrawn due to valvular heart disease, suicidal tendencies, cancer risk, or other reasons. Weight-loss drugs can reduce weight and bring metabolic benefits in obese patients, but also cause various side effects, including psychonervous system adverse reactions, cancer risk, cardiotoxicity, liver damage, pancreatic toxicity, renal toxicity, digestive tract side effects, etc. Drugs with severe side effects will receive a black box warning from the FDA, and drugs with fatal side effects will be ordered to withdraw from the market. In addition to summarizing the side effects of weight-loss drugs, this article put forward some in-depth considerations on their safety, in order to provide reference for pharmaceutical companies to develop weight-loss drugs, clinicians and patients to use weight-loss drugs correctly and protect people's lives and health.

obesity  /  weight loss pills  /  adverse reactions  /  safety  /  FDA
Wei ZHOU, Peng MA, Tian-shu XU, Li ZHANG, Guan-hua DU, Gui-fen QIANG. Progress in research on side effects of FDA listed weight-loss drugs and considerations on their safety[J]. Chinese Journal of New Drugs, 2023 , 32 (20) : 2113 -2120 .
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Year 2023 volume 32 Issue 20
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  • Online Date：2026-03-05
  • Published：2023-10-30
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  • Accepted：2023-08-10
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Affiliations
    1Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China
    2Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China
    3Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010107, China
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