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To evaluate the clinical safety and effectiveness of Jiuwei Zhike mixture in the treatment of wind-heat cough syndrome of acute bronchitis.
A randomized, double-blind, double-simulation, placebo and positive drug controlled, multi-center clinical trial design was adopted. The selected disease was acute bronchitis (wind-heat cough syndrome). Seven hundred subjects from 10 research centers were planned to be included and divided into treatment group, positive drug control group and placebo group in a ratio of 3∶1∶1. The patients took Jiuwei Zhike mixture+Jizhi syrup simulation agent, Jiuwei Zhike mixture simulation agent+Jizhi syrup, or Jiuwei Zhike mixture simulation agent+Jizhi syrup simulation agent for 7 d.
Jiuwei Zhike mixture took effect on acute bronchitis (wind-heat cough syndrome) from the 3rd day of administration. By the 7th day of administration, 54.7% of the subjects' cough symptoms completely disappeared (49.2% in the positive drug group and 15.1% in the placebo group), with a clinical recovery rate of about 51.6% (43.5% in the positive drug group and 13.7% in the placebo group), and a total effective rate of 93.4% (87.1% in the positive drug group and 41.9% in the placebo group). And it had a significant improvement effect on the symptoms of the disease.
Jiuwei Zhike mixture is safe and effective in treating acute bronchitis (wind-heat cough syndrome) and its curative effect is not inferior to Jizhi syrup and superior to placebo.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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