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As a sensor of environment-cell interaction, aryl hydrocarbon receptor (AhR) plays an important role in maintaining barrier function, immune system and antioxidant process of the skin. AhR regulates the expression of many genes that are related to basic skin functions. It is expressed in all types of skin cells and involved in the progression of a variety of inflammatory skin diseases, including atopic dermatitis and psoriasis. Due to the complexity of the AhR protein structure, its crystal structure has not been successfully resolved until researchers obtained the crystal structure of indirubin binding to HSP90-XAP2-AhR complex recently. Clinical studies have shown that activation of the AhR pathway by ligands is of significance to the treatment of inflammatory skin diseases, as demonstrated by the clinical success of an AhR agonist, Benvitimod, for the treatment of psoriasis. This article presents a brief review on the role of AhR in inflammatory skin diseases and the current progress in drug development.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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