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Investigating the mechanisms of total alkaloids of Strychnos against myasthenia gravis in a rat model
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Han-xing LIU1, Xing HUANG1, Xue-chun WU1, Lu LI1, Bin-bin DAI1, Xin-zhuang ZHANG1, Liang CAO1, Yong-wen ZHANG2, Wei XIAO1, *
Chinese Journal of New Drugs | 2026, 35(18) : 1968 - 1976
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Chinese Journal of New Drugs | 2026, 35(18): 1968-1976
Investigating the mechanisms of total alkaloids of Strychnos against myasthenia gravis in a rat model
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Han-xing LIU1, Xing HUANG1, Xue-chun WU1, Lu LI1, Bin-bin DAI1, Xin-zhuang ZHANG1, Liang CAO1, Yong-wen ZHANG2, Wei XIAO1, *
Affiliations
  • 1State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd.), Nanjing 211112, China
  • 2Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2026-09-30 doi: 10.20251/j.cnki.1003-3734.2026.18.009
Outline
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Objective:

To investigate the therapeutic effect of MQZZJ (total alkaloids of Strychnos) on experimental autoimmune myasthenia gravis (EAMG) rats and to elucidate its underlying mechanisms.

Methods:

The EAMG rat model was established by immunizing female Lewis rats with the R97-116 peptide fragment. Rats were assigned to different groups and treated with MQZZJ (0.35, 0.7, and 1.4 mg·kg-1) or prednisone (4.2 mg·kg-1). The therapeutic effects and potential mechanisms were evaluated by monitoring the Lennon score and rotarod falling speed, measuring serum levels of acetylcholine receptor antibody (AChR-Ab), IgG, IgG1, IgG2b, IFN-γ, IL-17, and TGF-β, and detecting the CD4+/CD8+ ratio in peripheral blood lymphocytes.

Results:

MQZZJ significantly reduced the Lennon score, increased the rotarod falling speed, and reduced serum levels of AChR-Ab, IgG, and the IgG2b subtype. It also significantly decreased serum IL-17 and IFN-γ levels, increased serum TGF-β levels, and reduced the CD4+/CD8+ ratio.

Conclusion:

MQZZJ can markedly ameliorate myasthenic symptoms in EAMG rats. The mechanism may be related to inhibiting AChR-Ab production, reducing the CD4+/CD8+ ratio, modulating immune dysfunction, and alleviating abnormal inflammation.

myasthenia gravis  /  total alkaloids of Strychnos  /  AChR-Ab  /  CD4+/CD8+  /  cytokines
刘涵星, 黄醒, 吴雪纯, 李璐, 代斌斌, 张新庄, 曹亮, 张永文, 肖伟. 马钱子总碱治疗重症肌无力大鼠模型的机制研究. 中国新药杂志, 2026 , 35 (18) : 1968 -1976 . DOI: 10.20251/j.cnki.1003-3734.2026.18.009
Han-xing LIU, Xing HUANG, Xue-chun WU, Lu LI, Bin-bin DAI, Xin-zhuang ZHANG, Liang CAO, Yong-wen ZHANG, Wei XIAO. Investigating the mechanisms of total alkaloids of Strychnos against myasthenia gravis in a rat model[J]. Chinese Journal of New Drugs, 2026 , 35 (18) : 1968 -1976 . DOI: 10.20251/j.cnki.1003-3734.2026.18.009
Appendix
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Year 2026 volume 35 Issue 18
56
9
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.18.009
  • Online Date：2026-10-26
  • Published：2026-09-30
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History
  • Accepted：2026-01-05
Funding
Affiliations
    1State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd.), Nanjing 211112, China
    2Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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