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Research advances in molecular imaging probes targeting CLDN18.2 in tumors
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Hao-qun MA1, 2, Xuan-hui PENG1, 2, Meng ZHENG1, 2, Yan WANG1, 2, Li-yan MIAO1, 2, *
Chinese Journal of New Drugs | 2026, 35(16) : 1712 - 1719
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Chinese Journal of New Drugs | 2026, 35(16): 1712-1719
Research advances in molecular imaging probes targeting CLDN18.2 in tumors
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Hao-qun MA1, 2, Xuan-hui PENG1, 2, Meng ZHENG1, 2, Yan WANG1, 2, Li-yan MIAO1, 2, *
Affiliations
  • 1Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
  • 2College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China
Published: 2026-08-30 doi: 10.20251/j.cnki.1003-3734.2026.16.005
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Claudin 18.2 (CLDN18.2) has emerged as a promising molecular target for anti-tumor therapy, drawing considerable attention in recent years. Although several CLDN18.2-targeted therapeutics have already entered clinical practice and shown good efficacy, their efficacy is closely correlated with the expression level of the target. Consequently, the development of molecular imaging probes with high sensitivity and specificity for CLDN18.2 is of great significance for the early detection of tumors, stratification of patients, and real-time monitoring of therapeutic response. This review systematically summarizes recent advances in the development of CLDN18.2-targeted molecular imaging probes, aiming to provide a theoretical framework to support the future design and clinical translation of diagnostic radiopharmaceuticals.

CLDN18.2  /  molecular imaging probe  /  radionuclide  /  tumor diagnosis  /  targeted therapy  /  clinical application
麻浩群, 彭渲惠, 郑梦, 王燕, 缪丽燕. 靶向肿瘤CLDN18.2分子影像探针的研究进展. 中国新药杂志, 2026 , 35 (16) : 1712 -1719 . DOI: 10.20251/j.cnki.1003-3734.2026.16.005
Hao-qun MA, Xuan-hui PENG, Meng ZHENG, Yan WANG, Li-yan MIAO. Research advances in molecular imaging probes targeting CLDN18.2 in tumors[J]. Chinese Journal of New Drugs, 2026 , 35 (16) : 1712 -1719 . DOI: 10.20251/j.cnki.1003-3734.2026.16.005
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Year 2026 volume 35 Issue 16
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doi: 10.20251/j.cnki.1003-3734.2026.16.005
  • Online Date：2026-10-26
  • Published：2026-08-30
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  • Accepted：2025-10-27
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    1Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
    2College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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