Full
Outline
Alzheimer's disease (AD) is a neurodegenerative disorder caused by the synergistic interplay of multiple factors. Current treatments are only able to alleviate symptoms and cannot cure or prevent it. Numerous studies have demonstrated that Chinese herbal essential oils can be administered through inhalation, topical application, and oral administration. Via multiple pathways including anti-amyloid-beta (Aβ) deposition, anti-abnormal Tau protein hyperphosphorylation, anti-oxidant stress, anti-inflammatory, anticholinesterase activity, and regulation of glucose metabolism, these oils improve the pathological features of AD, inhibit neurotoxicity and cell apoptosis, reduce neuronal damage, and ameliorate cognitive dysfunction. This paper systematically reviews the effects, molecular mechanisms, and administration routes of Chinese herbal essential oils intervening in AD, summarizes current research limitations and future development directions, and provides a reference for related basic research and new drug development.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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