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Research progress on human norovirus cultivation model
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Qing-chuan YU1, 2, 3, 4, Cai-min WEN1, 5, Yan LIU1, 2, 3, 4, Xiang-dong GAO5, Zhong-yu HU1, 2, 3, 4
Chinese Journal of New Drugs | 2026, 35(15) : 1592 - 1604
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Chinese Journal of New Drugs | 2026, 35(15): 1592-1604
Research progress on human norovirus cultivation model
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Qing-chuan YU1, 2, 3, 4, Cai-min WEN1, 5, Yan LIU1, 2, 3, 4, Xiang-dong GAO5, Zhong-yu HU1, 2, 3, 4
Affiliations
  • 1National Institutes for Food and Drug Control, Beijing 102629, China
  • 2State Key Laboratory of Drug Regulatory Science, Beijing 102629, China
  • 3NHC Key Laboratory of Research on Quality and Standardization of Biotech Products Beijing 102629, China
  • 4NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, Beijing 102629, China
  • 5China Pharmaceutical University, Nanjing 211100, China
Published: 2026-08-15 doi: 10.20251/j.cnki.1003-3734.2026.15.004
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Norovirus is one of the main pathogens causing viral diarrhea. Due to the lack of ideal in vitro cell culture models and animal models, research on the mechanisms of human norovirus (HuNoV) infection and replication, immune response, antiviral drug screening, and vaccine evaluation had been hindered. This review covers studies from 2003 to 2025, examining the feasibility, advantages, and limitations of both cell culture models and animal models. For cell models, most immortalized cell lines fail to support HuNoV replication; while intestinal organoids have successfully supported virus culture, the procedure is complex and may face ethical constraints. Human salivary gland cell lines, established in recent years, can stably support HuNoV replication and are low-cost, easy to operate, thus serving as an important alternative system. For animal models, high costs and immune responses that differ markedly from natural infections have limited their widespread use. By the summarizing and discussing these culture models, this review aims to consolidate previous findings and offer directions for improving existing models and developing new ones.

human norovirus  /  cell models  /  animal models  /  human intestinal enteroids  /  human salivary gland cell lines
于晴川, 温才敏, 刘艳, 高向东, 胡忠玉. 人诺如病毒培养模型研究进展. 中国新药杂志, 2026 , 35 (15) : 1592 -1604 . DOI: 10.20251/j.cnki.1003-3734.2026.15.004
Qing-chuan YU, Cai-min WEN, Yan LIU, Xiang-dong GAO, Zhong-yu HU. Research progress on human norovirus cultivation model[J]. Chinese Journal of New Drugs, 2026 , 35 (15) : 1592 -1604 . DOI: 10.20251/j.cnki.1003-3734.2026.15.004
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Year 2026 volume 35 Issue 15
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.15.004
  • Online Date：2026-10-26
  • Published：2026-08-15
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  • Accepted：2026-04-15
Funding
Affiliations
    1National Institutes for Food and Drug Control, Beijing 102629, China
    2State Key Laboratory of Drug Regulatory Science, Beijing 102629, China
    3NHC Key Laboratory of Research on Quality and Standardization of Biotech Products Beijing 102629, China
    4NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, Beijing 102629, China
    5China Pharmaceutical University, Nanjing 211100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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